Which narcotic is noted for having a lower risk of causing constipation?

Fentanyl is recognized for having a lower risk of causing constipation compared to other narcotics. This reduced gastrointestinal side effect occurs because fentanyl is a synthetic opioid that primarily binds to the mu-opioid receptors in the central nervous system rather than in the gastrointestinal tract. As a result, while it effectively provides analgesia, it is less likely to produce the constipation commonly associated with other opioids, such as morphine and codeine, which have a greater tendency to affect the gastrointestinal motility.

Morphine, hydromorphone, and codeine are all known to significantly decrease gut motility, which can lead to constipation, one of the more common side effects associated with opioid use. Fentanyl’s unique properties make it a preferred choice in scenarios where minimizing the risk of constipation is especially important, such as in patients who may be more susceptible to this side effect or those requiring long-term opioid management.