Which is considered the fluid of choice for resuscitation in septic shock?

In the context of resuscitation for septic shock, 0.9% normal saline is often considered the fluid of choice because it remains isotonic when administered. This characteristic helps expand intravascular volume effectively, which is vital in managing septic shock where significant fluid losses and vasodilation occur.

The primary goal during resuscitation is to restore perfusion to vital organs and maintain blood pressure. Normal saline is widely used due to its availability, cost-effectiveness, and established safety profile, although consideration of its potential effects on acid-base balance and electrolytes is necessary in clinical practice.

While options like 0.45% normal saline may lead to hypotonicity and are not suitable for rapid volume expansion, and 5% dextrose in water does not provide the necessary electrolytes for effective resuscitation, lactated Ringer's solution, although it is a suitable option for fluid resuscitation, is less commonly indicated as first-line treatment in septic shock compared to normal saline.