What is the recommended treatment for asymptomatic pancreatic pseudocyst?

The recommended treatment for an asymptomatic pancreatic pseudocyst is supportive care, which includes avoiding oral intake (nothing by mouth, or PO). This management approach is based on the understanding that many asymptomatic pancreatic pseudocysts, which are fluid collections that arise following pancreatitis, can resolve spontaneously over time without intervention.

When a pseudocyst is asymptomatic, the risks associated with surgical intervention, catheter drainage, or antibiotic therapy typically outweigh the benefits. Instead, patients are monitored closely, and supportive measures are taken to ensure that any associated pancreatic inflammation can resolve naturally.

Surgical intervention or catheter drainage might be indicated if the pseudocyst becomes symptomatic or exhibits complications such as infection, rupture, or significant growth. Antibiotic therapy is not routinely used for asymptomatic pseudocysts, as these do not typically present with signs of infection or require antimicrobial treatment. Therefore, supportive care with a focus on monitoring is the most appropriate course of action for managing asymptomatic pancreatic pseudocysts.