What is one of the most common complications associated with Peutz-Jeghers syndrome (PJS)?

Intussusception is recognized as one of the most common complications associated with Peutz-Jeghers syndrome (PJS). This syndrome is characterized by the development of hamartomatous polyps in the gastrointestinal tract, particularly in the small intestine, which can lead to obstruction. Intussusception occurs when one segment of the intestine telescopes into another, which can be triggered by the presence of these polyps.

Patients with PJS are at increased risk for this phenomenon because the polyps can act as a lead point for the intussusception. When the polyp protrudes into the lumen of the bowel, it can pull along the segment of bowel that it is attached to, causing an obstruction and, if not treated, potentially leading to bowel ischemia.

While the other options present serious concerns relevant to PJS, such as gastric cancer and duodenal obstruction, they occur less frequently as direct complications compared to the risk of intussusception due to the polypectomy process and management approaches in these patients.