What are the manifestations of severe selenium deficiency?

Severe selenium deficiency is primarily associated with skeletal muscle dysfunction and cardiomyopathy, a condition referred to as Keshan disease. This form of cardiomyopathy manifests as heart muscle inflammation and can lead to a range of symptoms, including heart failure, arrhythmias, and overall diminished cardiac function.

Selenium plays a crucial role in maintaining the health of skeletal muscle through its incorporation into selenoproteins, which are vital for antioxidant defense and thyroid hormone metabolism. Consequently, when selenium levels are significantly low, the muscles can weaken, leading to difficulties in movement and exercise intolerance.

Additionally, while other choices might present symptoms associated with various nutrient deficiencies or conditions, they do not specifically relate to selenium deficiency. For instance, hair loss and skin rashes might be seen in zinc deficiency, and frequent infections could be indicative of multiple nutrient imbalances or immune disorders. Thus, the most direct and recognized manifestations of severe selenium deficiency are indeed related to skeletal muscle and cardiac health.