What are common symptoms of graft versus host disease?

Graft versus host disease (GVHD) typically presents with notable systemic symptoms resulting from the immune response of donor cells against the recipient's tissues. The correct answer highlights a combination of manifestations that are characteristic of this condition.

A rash is often the most recognizable symptom and can range from mild to severe, sometimes resembling that of a skin reaction. The fever reflects an underlying inflammatory response as the immune system becomes activated. Diarrhea is common and may accompany gastrointestinal tract involvement due to the donor's immune cells attacking the intestinal lining. Liver dysfunction in GVHD occurs due to immune-mediated damage to the liver, leading to elevated liver enzymes, jaundice, and other signs of hepatic compromise.

This symptomatology is a direct consequence of the immune system targeting the host's healthy tissues, which is the hallmark of GVHD, especially post-hematopoietic stem cell transplantation.

While other options present symptoms that may align with various other conditions, they do not encapsulate the classic triad of symptoms associated with graft versus host disease effectively.